Lead Bioinformatician/Computational Biologist

Summary

Join Natera's innovative team as a Senior Bioinformatician/Computational Biologist and leverage your expertise in NGS, quantitative biology, and methods development to advance high-volume clinical diagnostic sequencing initiatives. You will drive the development of novel NGS assays, design and implement robust analysis tools and pipelines, collaborate with wet lab scientists to optimize workflows, partner with clinical staff for assay validation and deployment, and contribute expertise throughout the entire process flow. This role requires a PhD or MS in a related field, 4+ years of industry experience in clinical diagnostics, demonstrated expertise in DNA/RNA sequencing data analysis, proficiency with public genomics data sources, strong programming skills in Python, experience in high-performance computing, and knowledge of cloud computing platforms. The ideal candidate will also possess experience in clinical diagnostics development, a track record of deploying bioinformatics pipelines, and strong communication skills. Natera offers competitive benefits including comprehensive medical, dental, vision, life and disability plans, free testing for employees and their families, fertility care benefits, pregnancy and baby bonding leave, 401k benefits, and more.

Requirements

• PhD or MS in Bioinformatics, Computational Biology, Genomics, or related field
• 4+ years of industry experience in clinical diagnostics or related field
• Demonstrated expertise in DNA/RNA sequencing data analysis and interpretation
• Proficiency working with public genomics data sources (HapMap, dbSNP, 1000 Genomes Project, TCGA, GTEx, UK Biobank)
• Strong programming skills in Python and experience with scientific/bioinformatics libraries
• Experience working in high-performance computing environments (Kubernetes, SGE, LSF, SLURM)
• Practical knowledge of cloud computing platforms, particularly AWS or GCP
• Familiarity with workflow orchestration languages such as WDL and Nextflow

Responsibilities

• Drive the development of novel NGS assays for clinical diagnostic applications as part of a dynamic, cross-disciplinary team of molecular and computational biologists
• Design and implement robust analysis tools and pipelines for processing diagnostic assays across tumor, germline, and cell-free DNA samples
• Collaborate closely with wet lab scientists to build, troubleshoot, and optimize complex, high-throughput NGS workflows involving diverse sample types and analytical targets
• Partner with clinical staff to validate and successfully deploy assays into production environments
• Contribute expertise throughout the entire process flow—from initial sequencing through validation and production implementation

Preferred Qualifications

• Experience in clinical diagnostics development and regulatory requirements
• Track record of developing and deploying production-grade bioinformatics pipelines
• Publications or patents in relevant fields
• Strong communication skills and ability to collaborate across technical and non-technical teams

Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents
• Free testing in addition to fertility care benefits
• Pregnancy and baby bonding leave
• 401k benefits
• Commuter benefits