Principal Scientist, Biomarker Discovery & Development

Summary

Join Apogee Therapeutics as a Principal Scientist, Biomarker Discovery and Development! This newly created role involves executing biomarker strategies for clinical programs in immunology and inflammatory indications. You will collaborate with internal and external teams, analyze biomarker data, and support the design of biomarker discovery studies. The ideal candidate has a PhD or MS with relevant experience in biomarker discovery and validation. Apogee offers a competitive compensation and benefits package, including flexible PTO, company-wide shutdowns, and professional development opportunities. The position requires 10-15% travel.

Requirements

• PhD with 5 plus years, or MS with 8 plus years of pharmaceutical/biotech industry experience
• Experience in biomarker discovery, validation, and clinical implementation
• Good understanding of drug development stages and how to design biomarker strategies to support clinical development
• Experience working on cross-functional teams within a biotech/pharmaceutical environment
• Excellent communication, project management, and leadership skills
• Successfully exhibit Apogee’s C.O.R.E. values: Caring, Original, Resilient and Egoless

Responsibilities

• Collaborate with internal teams and external partners (CROs) to support the execution of biomarker strategies for clinical programs
• Manage day-to-day operations of biomarker strategies for clinical programs, including resourcing and oversight of assay selection, feasibility, troubleshooting, qualification, and clinical sample testing, jointly with the RTM Operations Team
• Analyze and interpret biomarker data, integrating findings with clinical and translational research insights
• Support the design and management of biomarker discovery studies, including but not limited to academic collaborations and ex vivo experiments
• Support the review of clinical study-related documents, including study protocol, lab manual, analysis plan, as well as publications related to biomarker findings
• Stay current with emerging biomarker technologies, regulatory guidelines, and industry best practices to refine biomarker approaches

Preferred Qualifications

• Experience in I&I indications in Respiratory such as asthma and COPD
• Hands-on experience with omics technologies (e.g., NGS, proteomics) and biomarker assay development (e.g., flow cytometry, immunoassays, mass spectrometry)
• Proficiency in data analysis tools (e.g., R, Python) to support biomarker discovery and development efforts

Benefits

• A great culture, grounded in our C.O.R.E. values: C aring, O riginal, R esilient and E goless
• Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture and company, wear multiple hats, and learn quickly
• Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits
• Flexible PTO
• Two, one-week company-wide shutdowns each year
• Commitment to growing you professionally and providing access to resources to further your development
• Apogee offers regular all team, in-person meetings to build relationships and problem solve