Scientist, Technology Development

Summary

Join Caribou Biosciences, a leading clinical-stage CRISPR genome-editing biopharmaceutical company, as a Scientist/Senior Scientist in our Technology Development group. You will lead research efforts to develop and optimize in vivo CRISPR platforms for therapeutic applications. This role involves designing and developing genome editing strategies, establishing in vivo models, optimizing delivery systems, and analyzing data. You will also collaborate with team members, manage projects, and mentor junior researchers. This is an exciting opportunity to drive discovery and contribute to Caribou's next-generation CRISPR therapy programs. The position offers a competitive salary and benefits package, including comprehensive health insurance, retirement plan, paid time off, and professional development opportunities.

Requirements

• Ph.D. in Molecular Biology, Genetics, Biochemistry, Neuroscience or a related field
• Minimum 3 years of relevant experience (postdoctoral or industry)
• Hands-on experience with in vivo models (e.g., mouse, rat, or non-human primates), including study design, execution, and analysis
• Proficiency in molecular biology techniques, including cloning, PCR, and NGS library preparation
• Experience in planning and executing in vitro functional assays
• Proven track record of problem solving and the ability to adapt and integrate new technologies into existing projects
• Highly organized with excellent communication and critical thinking skills. Self-motivated with a strong collaborative mindset
• Ability to develop and mentor a team of researchers
• Comfort in a fast-paced environment and ability to adjust workload based upon changing priorities
• Strong analytical and problem-solving skills with a detail-oriented mindset
• Ability to manage multiple projects and work both independently and in a team-oriented environment
• Excellent communication and presentation skills for conveying complex scientific concepts
• Innovative mindset with a passion for advancing genome editing technologies

Responsibilities

• Design and Develop Genome Editing Strategies: Lead the design and optimization of CRISPR-based genome editing tools for in vivo applications, focusing on precision, efficiency, and safety
• In Vivo Model Development: Establish and utilize relevant animal models to evaluate the performance of CRISPR systems in various tissues and disease contexts
• Delivery System Optimization: Develop and test innovative delivery systems, such as lipid nanoparticles (LNPs) or viral vectors, to ensure effective and targeted delivery of CRISPR components to desired tissues
• Data Analysis and Interpretation: Perform genomic and transcriptomic analyses (e.g., NGS, qPCR, ddPCR) to assess on-target and off-target editing outcomes, integration events, and gene expression changes
• Collaboration and Leadership: Provide scientific guidance to junior team members, foster collaboration across interdisciplinary teams, and manage external research partnerships as needed
• Project Management: Drive projects from conceptualization through execution, ensuring alignment with company timelines and goals

Preferred Qualifications

• Familiarity with delivery technologies such as AAV and LNP in animal models
• Mouse genetics and transgenic animal model generation
• Experience with Next-Generation Sequencing (NGS) platforms
• Experience in multi-parameter flow cytometry and data analysis
• Familiarity with immune cell signaling pathways governing immune response, proliferation, differentiation, and metabolism
• Experience designing and performing genetic engineering on cultured mammalian cells
• Knowledge of regulatory requirements and preclinical study design for therapeutic development

Benefits

• Comprehensive compensation package, which includes competitive salary, bonus, and equity for all employees
• Salary Range: $135,000 to $165,000 - This represents the present low and high end of the Company’s pay range for this position. Actual pay will vary based on various factors, including but not limited to location, skill, experience, and performance
• Generous paid vacation time, in addition to company-observed holidays and floating holidays
• Excellent medical, dental, and vision insurance
• 401(k) retirement savings plan, which includes matching employer contributions
• Employee stock purchase plan (ESPP)
• Tuition reimbursement program