Senior Assay Development Specialist

Summary

Join Serna Bio as an Assay Development Specialist to contribute to early-stage drug discovery project timelines by leading experiment design.

Requirements

• Ph.D/MSc. molecular Biology or relevant field
• Extensive demonstrable experience leading small molecule screening and assay design development for high throughput assays for drug discovery, scaleup and tech transfer specifically with regards to developing assay with the correct signal window
• Demonstrated experience in the development of robust and validated high throughput screening assays for driving hit to lead and lead op for multiple drug discovery programs
• Extensive experience working in a remote environment, and computational teams to lead robust computationally driven data analysis, data management
• Experience in nucleic-acid based and protein based assays
• Experience in verifying assays are fit-for-purpose and suitable for data production
• Knowledge of challenges with assay setup

Responsibilities

• Act as an internal assay development specialist
• Design and development of small molecule high throughput screening assays
• Drive statistical analysis choices with the computational team
• Design and develop screening cascade for core programs in collaboration with drug discovery team
• Direct high-content, cell-based, biochemical and biophysical assay development for multiple targets
• Manage the transfer and implementation of assay cascades with CRO partners
• Design reporter vectors and led cell-line engineering activities with CROs
• Help implement data analysis workflows and develop business rules for dose-response curve QC, hit-calling and assay performance monitoring

Benefits

Remote work environment