Senior Scientist, Translational Medicine

Summary

Join Nuvalent, a dynamic oncology drug discovery company, as a Senior Scientist in Translational Medicine. Reporting to the Senior Director, you will lead biomarker strategy development and execution across developmental programs. Responsibilities include analyzing clinical biomarker data, overseeing activities at external labs, collaborating with cross-functional teams, and contributing to regulatory submissions. The ideal candidate possesses a Ph.D. or M.S. in a relevant field with significant industry experience and expertise in bioinformatics and oncology. Strong analytical, communication, and collaborative skills are essential. This role offers the opportunity to contribute significantly to the advancement of oncology therapeutics.

Requirements

• A Ph.D. in cancer biology, cell/molecular biology, genomic biology or equivalent with 3+ years of industry experience after PhD, or an M.S. with 10+ years of industry experience
• Proficient in bioinformatic skills including using R and/or python in data analysis and plotting
• Deep knowledge of oncology kinase pathways, tumor biology and drug resistance
• Knowledge of clinically relevant biomarker assay types (such as NGS, RNAseq, IHC/mIF, and FISH)

Responsibilities

• Lead the generation, analysis, and documentation of clinical biomarker data, including next generation sequencing with tissue and plasma samples, gene expression profiling, and histopathology assays
• Conduct in-depth analysis and interpretation of biomarker data including in the context of other types of clinical data, and present findings in internal meetings
• Overseeing activities at contracting clinical translational biomarker labs
• Oversee nonclinical translational biology studies, including monotherapy and/or combination studies in disease relevant models in CROs and collaborating labs
• Work closely with clinical operations and sample management to oversee activities at central labs and contribute to implement/improve sample strategy
• Effectively collaborate across internal functions including biology, clinical operations, clinical pharmacology, clinical science, data management, sample management, statistics, and quality, to ensure successful execution in the clinic
• Represent Translational Medicine within a cross functional multi-disciplinary clinical study team, provide biomarker/scientific support, to meet project milestones for translational medicine responsibilities
• Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions; lead or contribute to the development of abstracts, external presentations, and publications

Preferred Qualifications

• Experience in providing biomarker support for registrational trial(s) and/or companion diagnostics
• Highly self-motivated, strong in execution, with a track record of advancing projects/programs forward
• Excellent team player with a collaborative mindset and ability to work independently
• Strong organization skills, attention to details, with strong critical thinking, analytical thinking and trouble shooting skills
• Excellent verbal and written communication skills, and is able to communicate and present in a succinct manner