Adverum Biotechnologies is hiring a
Associate Scientist in United States

Summary

Adverum is seeking an Associate Scientist with molecular biology knowledge to join their Redwood City team. The role involves developing, characterizing, and validating optogenetic gene therapy vectors, and assisting with IND-enabling studies. This position reports to a Senior Scientist/Team Leader.

Requirements

• Minimum of a biological science or similar Bachelor’s degree with 6-8 years’ of relevant experience in a biotech company, or a Master’s degree with 4-5 years’ of relevant experience, or an equivalent combination of education and experience
• Broad knowledge base in molecular biology, and microbiology techniques
• Expertise in a variety of laboratory techniques such as recombinant DNA technology, including cloning, DNA/RNA isolation and analysis, PCR, RT-PCR, qPCR is required
• Expertise in sterile tissue culture techniques including, transfection, transduction, developing and maintaining cell lines is a must
• Must be proactive, cooperative, and willing to work in a small team environment
• Excellent verbal and written communication skills
• Proficient with MS Office and other commonly used software

Responsibilities

• Support the execution of assays for discovery and translational research
• Produce, purify, and characterize complex biological molecules like DNA, RNA, protein, and AAV
• Maintenance, transfection and transduction of different cell types
• Perform sample processing from a variety of tissue types
• Order and maintain sufficient inventory of materials and reagents for planned laboratory activities
• Follow established protocols and SOPs
• Ensure accurate laboratory records and project updates
• Participate in team meetings and present technical data
• Be involved with development, qualification, and transfer of bioanalytical methods to support preclinical and clinical assays
• Present results, conclusions, and implications to project teams
• Maintain excellent documentation of laboratory activities
• Perform routine lab maintenance

Preferred Qualifications

• Biochemical techniques including, western blot, flow cytometry, immunofluorescence, ELISA are highly desired
• Hands-on experience with the execution of bioassays using technologies including qPCR, ddPCR, MSD, Luminex, flow cytometry and cell-based potency assays are advantageous
• Experience with sample processing methods to support protein and nucleic acid detection from a variety of animal/human tissues
• Experience with other gene expression and protein detection analytical methods
• Experience with data analysis software like Prism, FlowJo, ImageJ and SoftMax Pro are a plus
• Background and understanding of AAV biology is preferable
• AAV production experience is advantageous
• Understanding or background with optogenetics and calcium imaging assays is also advantageous