Vaxcyte is hiring a
Associate Scientist I

Summary

Vaxcyte is hiring an Associate Scientist I to contribute to the development of a robust process for generating their proprietary pneumococcal conjugate vaccine. The successful candidate will optimize and troubleshoot synthesis and purification procedures, analyze conjugates using various methods, and support the development team. A BS or MS degree in Chemistry, Biochemistry or related discipline with 0-2 years of industrial experience is required, along with specific skills and personal qualities.

Requirements

• BS or MS Degree in Chemistry, Biochemistry or related discipline with 0-2 years of industrial experience
• Experience in setting up and carrying out chemical reactions. Experience with protein conjugation reactions is a major plus
• Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, size-exclusion chromatography, and tangential flow filtration (TFF)
• Hands on experience with analytical methods including reversed-phase HPLC, colorimetric assays, size-exclusion chromatography (SEC), and SDS-PAGE for characterization of reaction products
• Highly organized, strong attention to details and excellent record keeping/documentation abilities
• Critical thinking and ability to analyze data
• Eager and able to learn and understand new concepts
• Strong interpersonal skills and ability to communicate effectively with team members
• Ability to work under supervision and collaborate effectively with team members
• Committed to upholding high standards of integrity, professionalism, and safety in all aspects of work

Responsibilities

• Optimize and troubleshoot multi-step synthesis of protein-polysaccharide conjugates
• Analyze conjugates with several methods including colorimetric assays and multiple HPLC assays
• Purify conjugates using a variety of methods including size-exclusion chromatography and tangential flow filtration (TFF)
• Contribute to the development and execution of Design of Experiment (DoE) models for process development
• Support the development work toward a process characterization of conjugate vaccine
• Complete any assigned tasks in high quality and in a timely manner
• Maintain good documentation practices for recording experimental plans and results in electronic lab notebook and associated reports
• Assist in troubleshooting of instrumentation and test methods, including the ordering of supplies and maintenance of equipment
• Participate in group meetings, present results of work, interpret data, and report results in an accurate manner
• Work within a team environment and provide support to further team objectives

Benefits

• The compensation package will be competitive and includes comprehensive benefits and an equity component
• Salary Range: $74,000 – $88,000