Associate Scientist

Summary

The job is for an Associate Scientist in the Cell Biology group at Arcellx, a clinical-stage biotechnology company. The role involves handling primary human immune cells, producing research-scale lentivirus, conducting complex immune assays, and more. The ideal candidate should have relevant laboratory experience and proficiency with complex immune cell assays.

Requirements

• BS degree with 2+ years of full-time laboratory experience or thesis-based MS degree
• Familiarity with one or more of the following areas: cell therapy, T-cell biology, tumor immunology or the use of biologics in anti-cancer therapy
• Expertise in manipulating immune cells, particularly T cells, including purification, transfection/transduction, activation and expansion
• Proficiency with complex immune cell assays including multiparameter flow cytometry, in vitro cell based assays, and multiplex assays
• Ability to effectively multitask and collaborate across multiple projects in a fast-paced cross-functional environment
• Commitment to ethical scientific investigations and rigorous experimental methods

Responsibilities

• Handle, isolate and manipulate primary human immune cells (e.g. PBMC, BMMC, T cells and monocytes) and cultured cell lines
• Produce research-scale lentivirus, analyze lentiviral quality, and determine viral integration into cell lines or primary human T-cells
• Conduct complex immune assays including in vitro cell-based assays (e.g. cytotoxicity, proliferation, degranulation), multiplex assays (e.g. MSD) and live cell analysis (e.g. Incucyte)
• Flow cytometry acquisition and analysis to evaluate antigen expression and protein binding
• Process blood and tissues from animal studies for analysis
• Execute ELISAs (commercial kits and custom assays) to measure cytokines, proteins and/or other biomarkers
• Utilize common software including GraphPad Prism, Word, PowerPoint, Excel, Outlook, and Flow Cytometry Analysis Software (FlowJo) to analyze, record and present your results
• Communicate detailed observations on experiments and assist in the preparation of technical reports, summaries, and protocols
• Work both independently and collaboratively, and effectively plan, organize work activities, and prioritize task completion
• Assist in maintaining laboratory consumables

Benefits

• Competitive base salary
• Annual bonus based on company goals
• Equity (RSU) grant
• Relocation assistance for roles if required
• 100% coverage for medical, dental and vision for team members and dependents
• Unlimited vacation
• 3-day weekend every month
• Fully-paid parental leave for up to 6 months
• Tuition reimbursement
• 401k employer contribution