Clinical Program Operations Manager

Summary

Join Natera as a Clinical Program Operations Manager to lead the execution of oncology therapeutic clinical programs. You will manage complex timelines, coordinate cross-functional efforts, and build external relationships. This high-impact role requires strong oncology trial experience and a solution-oriented mindset. You will thrive in a fast-paced environment, taking initiative and leading through ambiguity. The position involves program execution, operational leadership, stakeholder engagement, and scientific contribution. Natera offers competitive benefits and a collaborative work environment.

Requirements

• Advanced degree (PhD, PharmD, MD, or MS) in a life science or clinical field is required
• Minimum 5 years of experience in clinical research with a strong emphasis on program management and oncology trials
• Proven ability to manage trial timelines and operations in a cross-functional, fast-moving environment
• Acts fast, follows through relentlessly, and owns outcomes under pressure
• Excellent communication, organizational, and leadership skills

Responsibilities

• Own, drive, and enforce comprehensive trial timelines, deliverables, and Gantt charts; ensure alignment across functions and hold teams accountable for execution
• Identify risks early and fix them fast
• Collaborate closely with internal functions (e.g., clinical operations, regulatory, quality, medical) and external CROs/vendors
• Ensure real-time visibility of program status for leadership and cross-functional partners
• Oversee study startup activities, including site selection, feasibility, and trial initiation
• Manage CRO relationships and performance, including KPIs, deliverables, and contracts
• Ensure operational readiness for investigator meetings, site visits, and data reviews, in collaboration with cross-functional teams
• Dive into the weeds when necessary and eliminate roadblocks without being asked
• Serve as the primary operational liaison for internal and external trial communications
• Prepare structured updates, dashboards, and risk logs for senior leadership and the steering committee
• Travel (up to ~25%) to clinical sites, CROs, investigator meetings, and key partners to ensure operational excellence, build relationships, and represent clinical leadership on the ground
• Foster strong relationships with investigators and site personnel to ensure engagement and performance
• Attend data review meetings and contribute to clinical insight generation and action plans
• Help translate scientific and clinical objectives into executable operational strategies and trial designs

Preferred Qualifications

Startup or small biotech experience strongly preferred

Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents
• Free testing in addition to fertility care benefits
• Pregnancy and baby bonding leave
• 401k benefits
• Commuter benefits
• A generous employee referral program