Medical Director, Clinical Development

Summary

Join Absci, a data-first AI drug creation company, as their Medical Director for Clinical Development. This pivotal role requires a highly skilled physician-scientist to lead multiple programs, shaping clinical strategy and execution from early development through pivotal trials in immunology and dermatology. Responsibilities include co-developing clinical development strategies, leading protocol authoring, building KOL networks, providing medical oversight, interfacing with regulatory authorities, and managing risks. The ideal candidate will possess an MD or equivalent with residency, 5+ years of industry experience leading global clinical programs, expertise in clinical trial design, and a proven track record of accelerating therapies. Absci offers a flexible work environment (remote, hybrid, or onsite) and a competitive compensation package.

Requirements

• Medical Degree (MD or equivalent) with residency; subspecialty training in immunology, dermatology, or related field preferred
• 5+ years’ industry experience in biotechnology or pharmaceuticals, with a record of leading global clinical programs and authoring successful protocols
• Demonstrated success accelerating therapies from early-stage to late development, including direct engagement with regulators
• Expertise in clinical trial design, biostatistics fundamentals, and data interpretation

Responsibilities

• Clinical Development Leadership
• Co-develop and co-own the clinical development strategy and lifecycle planning for assigned programs from a medical perspective
• Adjust plans rapidly in response to evolving corporate priorities, scientific insights, and market conditions
• Protocol & Trial Strategy
• Lead authoring of study concepts, protocols, investigator brochures, and key clinical sections of regulatory dossiers
• Translate high-level product concepts into efficient, innovative clinical trial designs that reduce time to market in collaboration with Translational Research
• KOL & Stakeholder Engagement
• Identify, recruit, and cultivate a global network of key opinion leaders aligned with program strategy
• Partner with investigators, patient-advocacy groups, and advisory boards to optimize trial feasibility and relevance
• Medical Oversight
• Analyze emerging clinical data, provide medical review of tables/listings/figures, and drive data-driven decisions
• Serve as Safety Officer as needed, ensuring participant safety and scientific integrity throughout execution
• Regulatory & Cross-Functional Collaboration
• Interface with FDA, EMA, and other health authorities; craft and defend clinical development arguments
• Collaborate closely with Clinical Operations, Translational Research, CMC, Regulatory and other functions to assure seamless program execution
• Risk Management
• Proactively surface clinical, operational, and regulatory risks; design and execute mitigation plans
• Champion a culture of quality, compliance, and continuous improvement

Preferred Qualifications

• Experience with monoclonal antibodies, cytokine/immune-modulating therapies, or other biologics
• Prior IND submission experience
• Familiarity with AI-enabled drug discovery or data-rich translational approaches

Benefits

• Medical, dental, and vision benefits
• Employee stock purchase plan
• Highly competitive salaries
• Medical, dental, vision insurance
• Unlimited vacation
• Parental leave
• Breakfast and lunch for onsite employees
• Employee assistance program
• Voluntary life and disability insurance
• Annual bonus potential
• 401(k) with a generous company match