Senior Medicinal Chemist

Summary

Join SandboxAQ's AI Simulation team as a Senior Medicinal Chemist and contribute to the discovery of novel medicines using AI and physics-based computational solutions. You will apply organic and medicinal chemistry expertise to drug discovery projects, collaborating with multidisciplinary teams including computational chemists, AI experts, and software engineers. Leverage your knowledge of modern synthetic organic chemistry and medicinal chemistry principles to provide strategic input and technical direction. This role involves leading and managing contract research organizations (CROs) and external chemistry partners. You will also contribute to scientific publications and represent SandboxAQ externally. This is a unique opportunity to directly impact the development of innovative medicines using cutting-edge technology.

Requirements

• PhD in synthetic organic chemistry or medicinal chemistry or a related discipline
• More than 3 years of relevant experience including organic and medicinal chemistry expertise applied to drug discovery in the private sector e.g biotech or pharma
• Experience contributing to structure-based and ligand-based drug discovery programs and familiarity with computational methods
• Outstanding synthetic chemistry background and a demonstrated track record of aptitude and problem-solving in medicinal chemistry
• Experience leading the chemistry function within drug discovery projects
• Experience executing drug discovery programs from HitID to Candidate delivery with a consistent track record, working in multidisciplinary teams
• Experience in working with and closely managing a number of CRO resources and external chemistry partners
• A drive to cooperate with colleagues to identify problems and communicate scientific solutions in an accessible manner
• Hands-on mentality & comfortable with getting deep into complex problems, and a track record of contributing to projects and publications

Responsibilities

• Apply organic and medicinal chemistry strategies to address unmet drug discovery needs
• Apply your knowledge and track record of modern synthetic organic chemistry and medicinal chemistry principles to provide strategic input and technical direction
• Translate insights from drug discovery projects and work closely with the AI Sim computational chemistry and development teams to improve SandboxAQ's unique technology and Large Quantitative Models (LQMs) to deliver deep impact at scale
• Drive and collaborate with multidisciplinary teams to deliver scientific expertise and strategic direction in drug design problems
• Work in close collaboration with computational chemists, AI/ML experts, and cross-functional teams to prototype and scale cutting-edge, impactful drug design solutions
• Responsible for chemistry strategic alignment and effective resource allocation, leading and managing several contract research organizations (CRO) and external chemistry partners to deliver high-quality data in a timely manner
• Lead and collaborate in the preparation of scientific proposals, patents, reports and scientific publications supporting new and existing programs
• Represent SandboxAQ externally both with CROs and scientific partners
• Generate and evaluate hypotheses to assist design decisions and influence project direction
• Help to advance Sandbox’s computational design platform, working with our computational chemists and developers teams to accelerate the development of computational tools and algorithms

Preferred Qualifications

Preferably located on the East Coast of the US to enhance collaboration with EMEA team members

Benefits

• The US base salary range for this full-time position is expected to be $158k - $221k per year
• This role may be eligible for annual discretionary bonuses and equity
• Competitive salaries
• Stock options depending on employment type
• Generous learning opportunities
• Medical/dental/vision
• Family planning/fertility
• PTO (summer and winter breaks)
• Financial wellness resources
• 401(k) plans