Director, Computational Chemistry

Summary

The job description is for a full-time Computational Chemist at BridgeBio, a biopharmaceutical company specializing in genetic diseases and cancers with clear genetic drivers. The role involves working across the Computational Genetics team and the Early Discovery team, conducting computational analyses, interacting with various collaborators, staying current with state-of-the-art methods, and more.

Requirements

• Ph.D. in a computational chemistry or related discipline with multiple years of relevant experience in a biotech or pharma setting as part of medicinal chemistry programs
• Have experience in drug development projects that have later advanced into the clinic, with direct involvement during the DC nomination process
• Expert-level experience with a wide range of leading computational tools (e.g. Schrodinger, MOE, OpenEye, Molsoft) and approaches including both structure- and ligand-based techniques, ab initio methods, MD, FEP, homology modeling, docking, virtual screening, QSAR and QSPR predictions/model development with application across all stages of a project, from hit ID through to candidate nomination
• Extensive experience with Python focusing on data analysis; hands-on experience in developing data processing pipelines and or developing stand-alone libraries is a plus; familiarity with AWS infrastructure including EC2, S3
• Has direct experience or deep interest in the state-of-the-art AI applications with a deep understanding on where the advances can be applied practically in different company settings and drug discovery process
• Understanding of deep learning methods for molecular representation learning, as well as for predictive and generative tasks in drug discovery; experience developing or applying these methods is a plus
• The candidate should be driven, independent, experienced working in a cross-disciplinary team and thrive in a dynamic start-up environment
• Demonstrated track record of accomplishments, publications and conference presentations in computational chemistry and drug discovery
• Able to demonstrate great written and verbal communication skills in conveying analysis results to both experts and non-experts in the field

Responsibilities

• Design and execute initial computational analyses to derive an initial opinion regarding a target based on the knowledge of structure-based drug design, ADMET predictions, SAR, off-target selectivity and physiochemical properties
• Interact with both technical and non-technical collaborators, including biologists, physicians, geneticists, and business development & asset acquisition specialists, to evaluate new opportunities and derive analysis-based project decisions
• Contribute to project teams across all stages of a program, including target selection, target validation, lead generation and lead optimization to enable delivery of novel drug candidates into clinical development

Preferred Qualifications

Experience working with multiple CROs across geographic locations is a plus

Benefits

• Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
• An unyielding commitment to always putting patients first. Learn more about how we do this here
• A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
• A place where you own the vision – both for your program and your own career path
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
• Access to learning and development resources to help you get in the best professional shape of your life
• Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
• Flexible PTO
• Rapid career advancement for strong performers
• Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time
• Partnerships with leading institutions
• Commitment to Diversity, Equity & Inclusion