Scientist I

Summary

Join our Formulation and Drug Product Development team at Vaxcyte as we progress formulation development activities for our lead product candidate.

Requirements

• BSc or MSc in Pharmaceutics, Chemistry, Biophysics or Biochemistry preferred, with >4 years of industrial experience; or PhD in Pharmaceutics, Chemistry, Biophysics or Biochemistry with >2 years of relevant experience
• Experience of manufacturing within GxP environments either directly or through CMOs
• The candidate will have had extensive experience in developing proteins, polysaccharides and/or protein conjugates formulations for vaccines, preferably vaccine systems containing adjuvants (other biological experience also considered)
• Experience leading stability studies is required and the use of DoE for complex system optimization would be beneficial
• Experience in spectroscopic methodologies, particle light scattering analysis, quantitative subvisible particle analysis, visual inspection, is needed

Responsibilities

• Progressing formulation development activities, including stability studies for thermal, freeze/thaw, photostability and agitation as well as container closure system evaluation for both Drug Substance (DS) and Drug Product (DP) materials
• Performing formulation screening studies to support the selection of buffering conditions, stabilizers, and surfactants in vaccine formulations
• Apply biophysical characterization techniques to fully understand antigen/adjuvant interactions and to assess formulation matrix optimization options
• Supporting the manufacturing of formulations and critical reagents to facilitate tech transfer and the implementation of processes and analytical methods at CROs

Benefits

• Comprehensive benefits
• An equity component