Vice President, Commercial Operations

Summary

Join Amylyx Pharmaceuticals as their Vice President, Commercial Operations, a key member of the Commercial Leadership Team. You will establish and lead the commercial operations function, ensuring the necessary infrastructure, processes, and strategies for successful product commercialization. This role oversees various aspects of commercial operations, including sales operations, forecasting, analytics, incentive compensation, and market research. You will partner with multiple functions to drive commercial excellence and business growth. This is an opportunity to shape the Commercial Operations function from the ground up, supporting a high-impact product launch and long-term business growth. The role is anticipated to be filled in Q3 of 2025 and is a remote position with some travel required.

Requirements

• Bachelor's degree required; MBA or advanced degree preferred
• 12+ years in commercial operations, sales analytics, or related functions within the pharmaceutical, biotechnology, or healthcare industry
• Proven ability to build and lead high-performing teams in a fast-paced, evolving environment
• Strong business acumen with the ability to analyze complex data, forecast market trends, and drive strategic decision-making
• Demonstrated ability to work effectively across multiple departments, influencing senior leadership and cross-functional teams
• Experience with CRM systems, sales analytics, market insights, data governance, and incentive compensation design
• Strong written and verbal communication skills, with experience presenting insights to executive leadership and board members
• Ability to navigate ambiguity, prioritize initiatives, and implement innovative commercial solutions

Responsibilities

• Serve as a key member of the Commercial Leadership Team, developing and executing commercial strategy and operational plans
• Oversee the design and optimization of commercial operations, including market research, forecasting, data analytics, sales reporting, and performance tracking
• Develop a best-in-class commercial infrastructure that aligns with business objectives and supports pre-launch and post-launch activities
• Lead Quarterly Business Reviews (QBR) and Board of Directors (BoD) process preparation, including performance reporting and insights
• Partner cross-functionally with Marketing, Sales, Finance, Compliance, Market Access, and Medical Affairs to drive aligned strategic execution
• Design and implement field force structure, including sizing, territory alignment, and resource allocation
• Oversee field effectiveness, including CRM system implementation, sales enablement tools, and customer engagement reporting
• Develop and manage incentive compensation plans to motivate and retain top sales talent while ensuring compliance
• Establish field insights and reporting frameworks, providing timely and data-driven recommendations to sales leadership
• Support field training and development programs in collaboration with Sales Training teams
• Lead the development and governance of commercial data strategy, ensuring seamless integration and utilization of sales, claims, specialty pharmacy, and CRM data
• Develop competitive intelligence, customer targeting methodologies, and KPIs to assess commercial performance
• Design dashboards, analytics tools, and reporting mechanisms that provide actionable insights for leadership decision-making
• Partner with IT and external vendors to build and maintain a commercial data environment (CDE) that supports sales forecasting, revenue tracking, and strategic planning
• Manage commercial operations budgets, ensuring efficient allocation of human and financial resources
• Drive process improvements, system enhancements, and operational efficiencies to optimize commercial execution
• Oversee congress and event operations, including commercial presence at industry meetings
• Ensure compliance with industry regulations and internal policies in all commercial activities

Preferred Qualifications

Experience in rare diseases, specialty pharma, or product launches strongly preferred

Benefits

• At Amylyx, we proudly support remote work opportunities within the United States
• While this is a remote role, preference will be given to candidates who reside within New England and can attend meetings at our office in Cambridge, MA on an as-needed basis
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested