Vice President, Translational Data Science

Summary

Join a dynamic team at Recursion as Vice President, Translational Data Science/Computational Biology and drive the industrialization of drug discovery through advanced analytics and machine learning. Lead strategy and execution to identify diseases and patient populations, integrate genetic insights across monogenic and polygenic conditions, and develop translational biomarkers and patient selection solutions.

Requirements

• 7+ years applying expertise in computational biology leveraging the latest techniques in ML across drug discovery and development
• Key areas of prior experience include addressing problems in functional and statistical genetics with high-dimensional -omics data, particularly aimed at problems in target identification, mechanistic fine-mapping, as well as biomarker identification and development in precision medicine to enable patient stratification and response prediction
• A track-record for pairing large-scale patient/population datasets in a closed loop with high-throughput in vitro functional genomics and machine learning to transform the process of identifying targets, models, and biomarkers with patient connectivity and validity
• Experience in developing and implementing patient stratification / precision medicine solutions in clinical development leveraging multi-omics and clinical data and well versed in regulatory considerations
• Experience hiring, managing, and mentoring multiple teams engaged in drug discovery activities in a matrixed environment

Responsibilities

• Lead the strategy and execution to industrialize the process of identifying diseases and patient populations through novel gene-compound inferences informed by population-scale forward genetics and genome-scale reverse genetics data
• Integrate advanced machine learning methods to connect genetic insights across monogenic and polygenic conditions, ensuring that these discoveries are translated into actionable strategies for patient stratification, clinical trial design, and regulatory engagement across the entire drug development lifecycle
• Lead the strategy and implementation efforts to identify optimal disease and patient linkages to our -omics phenotypes, along with the discovery and validation of translational biomarkers and patient selection solutions to drive precision medicine for our therapeutic programs
• Drive the development and implementation of new computational tools including ML/DS approaches, algorithms, and methodologies
• Drive the integration of patient genetic and biomarker data collected in Recursion’s clinical trials to enable reverse translation , bridging clinical insights back into discovery programs
• Be a key member to contribute to strategy for data and diagnostic partnerships in support of the Recursion OS and clinical portfolio
• Collaborate closely with leaders in discovery biology, chemistry, and clinical sciences to accelerate the translation of data-driven insights into tangible therapeutic advancements
• Establish strong cross-functional partnerships to ensure that computational biology efforts are deeply integrated into the therapeutic area strategies
• Guide teams of computational biologists and data scientists in executing the above strategy to industrialize the process of turning maps into medicines
• Recruit, mentor, and manage high-performing teams of computational biologists and data scientists working in our therapeutic areas (oncology, neuroscience, and more) as well as on pan-therapeutic area initiatives, including genetics work

Benefits

• Estimated current annual base range for this role is: Developing £220,000, Skilled £243,000, Expert £268,000
• Eligible for bonuses and equity compensation + our comprehensive benefits package for United States based candidates