Director, Translational Sciences – Neuroscience

Summary

Join Arvinas, a clinical-stage biotechnology company, as a Director, Translational Sciences – Neuroscience. You will drive translational, clinical biomarker development, and clinical imaging strategies for our neuroscience portfolio. This role requires a strong scientific leadership background and extensive experience in leading translational strategies in neuroscience drug development. The position reports to the VP, Translational Sciences and offers a hybrid or remote work arrangement within the U.S. Arvinas offers a competitive compensation and benefits package. The ideal candidate will collaborate cross-functionally and manage a team, contributing to clinical trial success and regulatory submissions.

Requirements

• 6+ years of translational neuroscience drug development in the biotech or pharmaceutical industry that reflects demonstrated experience in the skills and competencies required of the role to work independently and assume full accountability for the functional area
• Clinical biomarker development such as fluid and tissue biomarker and digital biomarker solutions, and clinical implementation in neuroscience therapeutic area. Experience with patient stratification and selection strategy in clinical implementation is a plus
• Deep understanding of various biomarker technologies, experience with assay development and validation, operational aspects and relevant regulatory guidelines
• Experience with neuroimaging modalities, including PET, MRI, and molecular imaging techniques
• Demonstrated success in working on a cross-disciplinary, drug development project team, fostering collaboration and driving shared objectives
• Excellent communication and problem-solving skills; ability to work independently as well as collaboratively, preferably experienced in navigating and influencing in highly complex and matrixed environments
• Ability to work without a need for a current or future VISA sponsorship
• Ph.D. in Neuroscience, Neurophysiology, or a related life science field

Responsibilities

• Collaborates cross-functionally with Discovery, Clinical Development, Clinical Operations, Clinical Pharm, Regulatory, and other functions to support clinical program objectives
• Develops and implements translational, clinical biomarker development and clinical imaging strategies in clinical trials to support Arvinas neuroscience portfolio
• Manages the translational budget for the neuroscience portfolio
• Monitors execution and ensures timely fit-for-purpose pharmacodynamic/exploratory biomarker assay development and validation in partnership with external CROs and internal laboratory teams to support multi-site clinical trials for tauopathies, Parkinson’s Disease, Huntington’s disease, and other neurodegenerative diseases
• Leads the due diligence efforts on new biomarker technologies, vendor assessment/ selection to enable high quality biomarker analysis
• Manages and coaches the direct report to perform as the Translational Sciences Lead to support Arvinas neuroscience clinical programs
• Leads clinical biomarker subteams and collaborates cross-functionally to align on translational fluid and tissue biomarker strategy and digital biomarker solutions
• Assures effective delivery of biomarker data to support decision making in clinical studies and neuroscience portfolio progression
• Contributes to the clinical imaging strategy and execution, including PET, MRI, and other advanced neuroimaging modalities in collaboration with imaging CROs and internal teams to implement imaging readouts in clinical trials. Ensures neuroimaging endpoints are optimized for decision-making in early and late-stage clinical trials. Provides scientific leadership on imaging data interpretation
• Participates in the planning, writing, and review of biomarker and clinical imaging related sections for Clinical Trial Protocols, Clinical Study Reports, Investigatory Brochures, Biomarker Study Reports, manuscripts/abstracts, and regulatory submissions from IND to NDA
• Influences and collaborates with Discovery teams to align preclinical strategies with clinical needs and de-risk clinical development

Preferred Qualifications

A track record in leading translational strategies across multiple stages of clinical development, from IND to NDA / BLA, and global filing experience strongly preferred

Benefits

• Competitive package of base and incentive compensation
• Comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families
• Group medical, vision and dental coverage
• Group and supplemental life insurance