Clinical Data Manager - Oncology & Real-World Evidence

Summary

Join SOPHiA GENETICS Clinical Operations Team as a Clinical Data Manager of Oncology & Real-World Evidence (RWE) and contribute to improving outcomes for cancer and rare disease patients. Lead end-to-end data management for oncology observational and real-world studies. Define and maintain data management plans, data dictionaries, and quality control processes. Oversee data collection, validation, and cleaning. Apply clinical oncology knowledge to ensure meaningful data capture and interpretation. Collaborate with cross-functional teams, including biostatistics, medical, regulatory, and business development. Ensure data compliance with relevant standards.

Requirements

• Degree in Life Sciences, Pharmacy, biology, or equivalent (Master’s or higher preferred)
• Minimum 5 years of experience in data management for clinical or real-world studies
• Strong clinical background in oncology — ability to interpret clinical context from raw data
• Solid understanding of RWE study design, endpoints, and data sources
• Experience working in cross-functional, matrixes environments
• Strong communication skills; able to translate complex data into clear messages for internal and external stakeholders
• Fluent in English (written and spoken); French is a plus

Responsibilities

• Lead end-to-end data management activities for observational and real-world studies in oncology
• Define and maintain data management plans, data dictionaries, and quality control processes
• Oversee data collection, validation, and cleaning in collaboration with clinical and technical teams
• Apply clinical oncology knowledge to ensure meaningful data capture and interpretation
• Review and annotate CRFs, ensure consistency of clinical data with study objectives and endpoints
• Contribute to the development of medical and scientific content for internal trainings, study proposals, and publications
• Support discussions with clinical experts and oncologists by providing data-driven insights and context
• Interface with BioPharma partners in the context of collaborative efforts
• Collaborate cross-functionally with biostatistics, medical, regulatory, and business development teams
• Ensure data compliance with relevant standards (e.g., GPP, GDPR, FAIR principles, etc.)

Preferred Qualifications

Familiarity with CDISC standards, EDC systems, and relevant data privacy regulations is an asset

Benefits

• Sickness and Accident coverage through Helsana
• Meal Vouchers at 90CHF PM with our partner cafeteria
• A fun and engaging work environment, with Rest & Entertainment space, full stocked free coffee machine and free fruit/snacks
• Free parking in an easy to access location
• A strong social committee whose purpose is to make SOPHiA GENETICs both enjoyable as well as rewarding
• As our global HQ, you’ll have direct interaction and exposure to senior leadership and our executive team locally
• Forfait-Jour working types
• Health benefits for you and your family covered by 80% employer contributions
• Life Insurance and pensions contribution
• SWILE meal vouchers and home office allowances